%0 Journal Article %T Advanced research validates classical principles—the neurobiological mechanisms involved in acupuncture for pain management %A Gong, Changzhen %A Liu, Wei %J Longhua Chinese Medicine %D 2019 %B 2019 %9 %! Advanced research validates classical principles—the neurobiological mechanisms involved in acupuncture for pain management %K %X Classical acupuncture principle states that acupuncture produces a combination of local effect, distal effect and whole-body effect. How does modern science validate this combination-of-effect principle? This paper presents evidence that the effectiveness of acupuncture results from its local effect, segmental effect and general effect from a neurobiological perspective, which validates the classical principle. %U https://lcm.amegroups.org/article/view/5500 %V 2 %P %@ 2616-2806