Dale George Nagle, B.S.P., Ph.D.
Department of BioMolecular Sciences, University of Mississippi, University, Mississippi, USA
Dr. Dale G. Nagle is a Professor of Pharmacognosy in the University of Mississippi’s Department of BioMolecular Sciences. His research program focuses on the discovery and molecular pharmacology of natural product-based molecular-targeted antitumor agents. His group has discovered hundreds of antitumor plant and marine secondary metabolites. Dr. Nagle's team has extensive experience in the discovery of unique natural products that inhibit hypoxic signaling in tumors through the disruption of hypoxia-inducible factor (HIF)-regulated gene expression. His team has discovered dozens of terrestrial plant and marine natural products that inhibit HIF-1 in breast tumor models.
His research has also been aimed at the identification of ingredients in dietary supplements and Traditional Chinese Medicine (TCM) products that are associated with idiosyncratic organ-specific toxicities that may be mediated through mitochondrial disruption. He has published groundbreaking manuscripts that link botanical products and herbal intoxication events to their mitochondria-toxic phytochemical components.
Dr. Nagle’s program currently focuses on agents that interfere with the organ-specific genetic pre-programming of aggressive “triple-negative” breast tumor cells. His group is working to assess the antimetastatic breast cancer potential of TCM products. He has co-authored nearly 100 peer-reviewed publications, including 14 book chapters, an invited seminal chapter on “Natural Products as Probes of Selected Targets in Tumor Cell Biology and Hypoxic Signaling,” and another on “Mechanism-Based Screening for Cancer Therapeutics.”
Terms of Appointment: April 2018 - April 2020